| Identification | Back Directory | [Name]
ZED-1227 | [CAS]
1542132-88-6 | [Synonyms]
ZED-1227 ZED 1227,ZED1227 2-Heptenoic acid, 7-[[1-[2-[(2-ethylbutyl)amino]-2-oxoethyl]-1,2-dihydro-2-oxo-3-pyridinyl]amino]-6-[[(1-methyl-1H-imidazol-5-yl)carbonyl]amino]-7-oxo-, methyl ester, (2E,6S)- | [Molecular Formula]
C26H36N6O6 | [MDL Number]
MFCD30532544 | [MOL File]
1542132-88-6.mol | [Molecular Weight]
528.6 |
| Chemical Properties | Back Directory | [Boiling point ]
916.3±65.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
10.63±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
(2E,6S)-7-[[1-[2-[(2-Ethylbutyl)amino]-2-oxoethyl]-1,2-dihydro-2-oxo-3-pyridinyl]amino]-6-[[(1-methyl-1H-imidazol-5-yl)carbonyl]amino]-7-oxo-2-heptenoic Acid Methyl Ester is a derivative of pyridinone which serves as transglutaminase inhibitors. | [in vivo]
ZED-1227 reduces the activity of intestinal TG2 induced by Polyinosinic:Polycytidylic acid (40 mg/kg) to normal control levels and subdues intestinal inflammation in mice[1]. ?
ZED-1227 (5 mg/kg; i.g.) is able to inhibit TG2 in the small intestinal mucosa[2].
| Animal Model: | BALB/c mice[2] | | Dosage: | 5 mg/kg | | Administration: | Oral gavage | | Result: | Inhibited TG2 in vivo in the small intestinal mucosa. |
| [storage]
Store at -20°C |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|