| Identification | More | [Name]
5-Bromo-3-nitro-2-pyridinol | [CAS]
15862-34-7 | [Synonyms]
5-BROMO-2-HYDROXY-3-NITROPYRIDINE
5-BROMO-3-NITRO-2(1H)-PYRIDINONE
5-BROMO-3-NITRO-2-PYRIDINOL
5-BROMO-3-NITROPYRIDIN-2-OL
BUTTPARK 43\57-80
5-bromo-3-nitro-2-pyridone
3-Bromo-6-hydroxy-5-nitropyridine
2-Hydroxy-5-Bromo-3-NitroPyridine
2-Hydroxy-3-Nitro-5-Bromopyridine
5-Bromo-3-Nitropyridine-2-Ol
5-Bromo-3-nitro-2-pyridinol, 5-Bromo-2-hydroxy-3-nitropyridine
5-Bromo-3-nitro-2(1H)-pyridinone, 5-Bromo-3-nitro-2-pyridinol
5-bromo-3-nitro-1H-pyridin-2-one | [EINECS(EC#)]
239-989-0 | [Molecular Formula]
C5H3BrN2O3 | [MDL Number]
MFCD00023473 | [Molecular Weight]
218.99 | [MOL File]
15862-34-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
246-250 °C | [Boiling point ]
296.7±40.0 °C(Predicted) | [density ]
1.98±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO, Methanol | [form ]
Solid | [pka]
6.31±0.10(Predicted) | [color ]
Yellow | [BRN ]
383853 | [InChI]
InChI=1S/C5H3BrN2O3/c6-3-1-4(8(10)11)5(9)7-2-3/h1-2H,(H,7,9) | [InChIKey]
WXRLCVUDLFFTFF-UHFFFAOYSA-N | [SMILES]
C1(=O)NC=C(Br)C=C1[N+]([O-])=O | [CAS DataBase Reference]
15862-34-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20:Harmful by inhalation. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
2811 | [WGK Germany ]
3
| [Hazard Note ]
Harmful | [HazardClass ]
IRRITANT | [HS Code ]
29337900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
5-Bromo-3-nitropyridin-2(1H)-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | [Synthesis]
GENERAL METHOD: 2-amino-3-nitro-5-bromopyridine (0.015 mol) was dissolved in 70% sulfuric acid under cooling in an ice bath. A solution prepared from sodium nitrite (1.24 g) dissolved in water (8 mL) was slowly added dropwise in the range of 0-5°C, keeping the reaction temperature constant. After the dropwise addition, the reaction mixture was allowed to warm up gradually to room temperature and stirred continuously at that temperature for 3 hours. After completion of the reaction, the resulting precipitate was separated by filtration, washed well with deionized water and finally dried under vacuum at 60 °C overnight. | [References]
[1] Tetrahedron, 2014, vol. 70, # 5, p. 1077 - 1083
[2] Journal of the Chemical Society, 1952, p. 2042,2044
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999, vol. 38, # 9, p. 1036 - 1040 |
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