| Identification | More | [Name]
Rimonabant hydrochloride | [CAS]
158681-13-1 | [Synonyms]
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-n-1-piperidinyl-1h-pyrazole-3-carboxamide monohydrochloride
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-n-piperidinopyrazole-3-carboxamide
ACOMPLIA
RIMONABANT
RIMONABANT HYDROCHLORIDE
ACOMPLIA (RIMONABANT
RIMONABANT HCL
Rimonabant(Acomplia)
RimonabantConsultedStandard
Acomplia, SR141716
SR 141716A
5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide monohydrochloride | [EINECS(EC#)]
233-720-0 | [Molecular Formula]
C22H21Cl3N4O | [MDL Number]
MFCD04034714 | [Molecular Weight]
463.79 | [MOL File]
158681-13-1.mol |
| Chemical Properties | Back Directory | [Appearance]
White to Off-White Crystalline Solid | [Melting point ]
230-240°C | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [color ]
white to beige | [Usage]
The first of a new class of selective (Cannabinoid-1 (CB-1) receptor antagonists | [InChI]
1S/C22H21Cl3N4O.ClH/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15;/h5-10,13H,2-4,11-12H2,1H3,(H,27,30);1H | [InChIKey]
REOYOKXLUFHOBV-UHFFFAOYSA-N | [SMILES]
CC1=C(C2=CC=C(Cl)C=C2)N(C3=CC=C(Cl)C=C3Cl)N=C1C(NN4CCCCC4)=O.Cl | [CAS DataBase Reference]
158681-13-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xi | [Risk Statements ]
25-36 | [Safety Statements ]
26-45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Hazard]
A poison. | [Chemical Properties]
White to Off-White Crystalline Solid | [Uses]
Rimonabant hydrochloride has been used as an antagonist of cannabinoid 1 (CB1) receptor:
- to study its effects on protein synthesis in C2C12 myotubes
- to analyze its effects on human astroglia
- in combination with methanandamide (mAEA) to study its effects on murine gastric vagal afferent mechanosensitivity
| [Uses]
A brain cannabinoid receptor (CB1) antagonist. Antiobesity agent. | [Uses]
The first of a new class of selective (Cannabinoid-1 (CB-1) receptor antagonists | [Biochem/physiol Actions]
Rimonabant acts as a mycobacterial membrane protein large 3 (MMPL3) inhibitor. Rimonabant hydrochloride exhibits therapeutic activity against weight reduction and smoking cessation. | [storage]
Desiccate at RT |
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