| Identification | Back Directory | [Name]
4,7,10,13,16-Pentaoxanonadeca-1,18-diyne | [CAS]
159428-42-9 | [Synonyms]
Bis-propargyl-PEG5
Alkyne-PEG5-Alkyne
PROPARGYL-PEG5-PROPARGYL
Propyl ether-PEG3-Propyl ether
Tetraethylene glycol dipropargyl ether
4,7,10,13,16-Pentaoxanonadeca-1,18-diyne
1,11-bis(2-propyn-1-oxy)-3,6,9-trioxaundecane | [Molecular Formula]
C14H22O5 | [MDL Number]
MFCD22201533 | [MOL File]
159428-42-9.mol | [Molecular Weight]
270.32 |
| Chemical Properties | Back Directory | [Boiling point ]
338.7±37.0 °C(Predicted) | [density ]
1.043±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [form ]
Liquid | [color ]
Colorless to light yellow | [InChI]
1S/C14H22O5/c1-3-5-15-7-9-17-11-13-19-14-12-18-10-8-16-6-4-2/h1-2H,5-14H2 | [InChIKey]
FCPHAZIYRMYSTF-UHFFFAOYSA-N | [SMILES]
C#CCOCCOCCOCCOCCOCC#C |
| Hazard Information | Back Directory | [Description]
Bis-propargyl-PEG5 is a crosslinker containing propargyl groups at both ends. The propargyl groups reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to form stable triazole linkages. | [Uses]
Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers[1][2]. Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Pearlie BURNETTE, et al. Dimeric immuno-modulatory compounds against cereblon-based mechanisms. WO2020014489A2.
[2] Jiang, et al. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron, 2018: 74(27), 3527–3533. |
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