| Identification | Back Directory | [Name]
Ethylene Glycol 1,2-Bis(2-propynyl) Ether | [CAS]
40842-04-4 | [Synonyms]
Alkyne-PEG2-Alkyne
Bis-propargyl-PEG1
4,7-Dioxa-1,9-decadiyne
PROPARGYL-PEG2-PROPARGYL
1,2-Bis(propargyloxy)ethane
1,2-Bis(2-propynyloxy)ethane
1,2-bis(prop-2-yn-1-yloxy)ethane
ethylene glycol dipropargyl ether
Ethylene Glycol 1,2-Bis(2-propynyl) Ether
1-Propyne, 3,3'-[1,2-ethanediylbis(oxy)]bis-
Ethylene Glycol 1,2-Bis(2-propynyl) Ether > | [EINECS(EC#)]
808-107-1 | [Molecular Formula]
C8H10O2 | [MDL Number]
MFCD03640302 | [MOL File]
40842-04-4.mol | [Molecular Weight]
138.16 |
| Chemical Properties | Back Directory | [Boiling point ]
88°C/15mmHg(lit.) | [density ]
0.9502 g/cm3 | [refractive index ]
1.4550 to 1.4590 | [Fp ]
58° | [storage temp. ]
2-8°C, stored under nitrogen | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
clear liquid | [color ]
White to Yellow to Green |
| Hazard Information | Back Directory | [Description]
Bis-propargyl-PEG2 is a homobifunctional PEG linker with two propargyl groups. The propargyl groups forms triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. | [Uses]
Bis-propargyl-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bis-propargyl-PEG1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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TCI AMERICA
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