| Identification | Back Directory | [Name]
propargyl-PEG3-Acid | [CAS]
1347760-82-0 | [Synonyms]
1347760-82-0
Alkyne-PEG3-COOH
propargyl-PEG3-Acid
PROPARGYL-PEG3-COOH
Propargyl-PEG2-COOH
Propyne-PEG2-CH2CH2COOH
Propargyl-PEG2-CH2CH2COOH
Propargyl-PEG4-(CH2)3-acid
Propargyl-PEG3-Carboxylic Acid
3-[2-[2-(2-Propargyloxy)ethoxy]ethoxy]propanoic Acid
3-{2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy}propanoic acid
3-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoic acid
Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]- | [Molecular Formula]
C10H16O5 | [MDL Number]
MFCD22201521 | [MOL File]
1347760-82-0.mol | [Molecular Weight]
216.231 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG3-acid is a reagent with an alkyne group and a carboxylic acid. The terminal carboxylic acid can form amide bond with primary amines (activation is needed). The alkyne can form triazole linkage with azide containing molecules via copper catalyzed reactions. | [Uses]
Propargyl-PEG3-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG3-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. | [reaction suitability]
reagent type: linker | [IC 50]
PEGs; Non-cleavable Linker |
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