| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [form ]
Solid | [color ]
White to off-white | [Sequence]
Ser-Val-Asp-Asp-His-Phe-Ala-Lys-Ser-Leu-Gly-Asp-Thr-Trp-Leu-Gln-Ile-Gly-Gly-Ser-Gly-Asn-Pro-Lys-Thr-Ala-Asn-Val-Pro-Gln-Thr-Val-Pro-Met-Arg-Leu-Arg-Lys-Leu-Pro-Asp-Ser-Phe-Phe-Lys-Pro-Pro-Glu |
| Hazard Information | Back Directory | [Uses]
Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model[1]. | [Biological Activity]
Super-TDU is an inhibitory polypeptide targeting YAP-TEADs interaction. | [in vivo]
Super-TDU can treat gastric cancer by directly targeting YAP-TEADs, unlike the traditional drug compound 5-FU, whose antitumor activity tends to be more towards tumors with a high ratio of YAP/VGLL4. | [target]
| Target | Value | YAP/TEAD interaction
() |
| [IC 50]
YAP/TAZ-TEAD | [storage]
Store at -20°C | [References]
[1] Jiao S, et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell. 2014 Feb 10;25(2):166-80. DOI:10.1016/j.ccr.2014.01.010 |
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| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
| Company Name: |
Combio (Suzhou) Ltd.
|
| Telephone: |
17751201929; 17751201929 |
| Website: |
http://www.combiosz.com/ |
|