| Identification | Back Directory | [Name]
1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride | [CAS]
1620278-72-9 | [Synonyms]
TLR7/8 agonist-5d
8 agonist 1 dihydrochloride
TLR7/8 Agonist 1 (hydrochloride)
TLR7/8 agonist 1 (dihydrochloride)
1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride | [Molecular Formula]
C22H26ClN5 | [MDL Number]
MFCD31657341 | [MOL File]
1620278-72-9.mol | [Molecular Weight]
395.94 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:83.33(Max Conc. mg/mL);192.72(Max Conc. mM) | [form ]
A solid | [color ]
Off-white to light yellow | [InChI]
InChI=1S/C22H25N5.ClH/c1-2-3-8-19-26-20-21(17-6-4-5-7-18(17)25-22(20)24)27(19)14-16-11-9-15(13-23)10-12-16;/h4-7,9-12H,2-3,8,13-14,23H2,1H3,(H2,24,25);1H | [InChIKey]
IIFIHBPSMOIXGG-UHFFFAOYSA-N | [SMILES]
C(C1C=CC(CN)=CC=1)N1C(=NC2C(N)=NC3=CC=CC=C3C1=2)CCCC.Cl |
| Hazard Information | Back Directory | [Biological Activity]
TLR7/8 agonist 1 dihydrochloride is a dual agonist of the toll-like receptor TLR7/TLR8. | [in vitro]
TLR7/8 agonist 1 (Compound 5d) shows prominent immunostimulatory activities. TLR7/8 agonist 1 serves as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity.It retains TLR7- agonistic activity with an EC 50 of 20 nM. TLR7/8 agonist 1 (Compound 1) shows substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens. | [target]
| [storage]
Store at -20°C |
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