| Identification | Back Directory | [Name]
Hydrazinecarboxylic acid, 2-cyano-2-[2-[methyl(phenylmethyl)amino]-2-oxoethyl]-, 1,1-dimethylethyl ester | [CAS]
1627094-88-5 | [Synonyms]
Gü2602
Hydrazinecarboxylic acid, 2-cyano-2-[2-[methyl(phenylmethyl)amino]-2-oxoethyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C16H22N4O3 | [MOL File]
1627094-88-5.mol | [Molecular Weight]
318.37 |
| Chemical Properties | Back Directory | [density ]
1.171±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [form ]
Solid | [pka]
7.06±0.50(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Gü2602 is a potent, reversible cathepsin K (CatK) inhibitor with a Ki of 0.013 nM for mature CatK (mCatK). Gü2602 suppresses the autocatalytic activation of the cathepsin K zymogen[1]. | [IC 50]
cathepsin K | [storage]
4°C, away from moisture and light | [References]
[1] Beny?ek J, et al. Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem. 2022 Dec;37(1):515-526. DOI:10.1080/14756366.2021.2024527 |
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