| Identification | Back Directory | [Name]
STING-Inducer-1 | [CAS]
1638241-89-0 | [Synonyms]
MIW815
ML RR-S2 CDA
STING-Inducer-1
ML RR-S2 CDA;MIW815;STING-INDUCER-1
ML RR-S2 CDA;STING-INDUCER-1;1638241-89-0
Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide | [Molecular Formula]
C20H24N10O10P2S2 | [MDL Number]
MFCD28900737 | [MOL File]
1638241-89-0.mol | [Molecular Weight]
690.54 |
| Chemical Properties | Back Directory | [Boiling point ]
1020.8±75.0 °C(Predicted) | [density ]
2.43±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 2 mg/mL (2.90 mM) | [form ]
Solid | [pka]
-0.67±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
IZJJFUQKKZFVLH-UUXHIKLWNA-N |
| Hazard Information | Back Directory | [Uses]
ML-RR-S2-CDA is a stimulator of interferon genes (STING) agonist for cancer treatment. | [Biological Activity]
ADU-S100 (MIW815) is an activator of stimulator of interferon genes (STING) with potent antitumor and immune activity. | [in vivo]
ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8 + T cell responses, and improves long-term survival to 50%. | [target]
| [storage]
Store at -20°C |
|
| Company Name: |
shanghai Kezx
|
| Telephone: |
18017817217 13770021960 |
| Website: |
http://www.kezxbio.com/ |
|