| Identification | Back Directory | [Name]
6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride | [CAS]
1638644-62-8 | [Synonyms]
OD-36
OD-36,OD36
OD 36 hydrochloride
RIPK2 inhibitor OD36
13H-1,16-Etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine, 6-chloro-10,11,14,17-tetrahydro-
6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride | [Molecular Formula]
C16H15ClN4O2 | [MOL File]
1638644-62-8.mol | [Molecular Weight]
330.77 |
| Chemical Properties | Back Directory | [Boiling point ]
501.7±50.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at RT | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
4.79±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
OD 36 is a potent and selective inhibitor of RIPK2 (Receptor-Interacting serine/threonine-Protein Kinase 2). | [Biological Activity]
Cell permeable: yes''Primary Target
RIPK2 | [in vivo]
OD36 (6.25 mg/kg; i.p.; once) alleviates inflammation in an acute peritonitis mice model[3]. | Animal Model: | C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis[3] | | Dosage: | 6.25 mg/kg | | Administration: | Intraperitoneal injection, 30 min prior to MDP | | Result: | Inhibited the recruitment of inflammatory cells to the peritoneum, specifically that of neutrophils, and, to a lesser extent, lymphocytes. Decreased RIPK2-specific genes as well as inflammatory cytokine and chemokine gene expression. |
| [IC 50]
RIPK2: 5.3 nM (IC50); ACVR1: 37 nM (Kd); ACVR1: 47 nM (IC50); ALK2 R206H: 22 nM (IC50) | [storage]
Desiccate at RT |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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