| Identification | Back Directory | [Name]
MC-VC-PABC-DNA31 | [CAS]
1639352-03-6 | [Synonyms]
MC-VC-PABC-DNA31
Rifamycin VIII, 1',4-didehydro-5'-[4-[[[[4-[[N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]amino]-1-piperidinyl]-1,4-dihydro-3'-hydroxy-1-oxo- | [Molecular Formula]
C77H96N10O21 | [MDL Number]
MFCD32197308 | [MOL File]
1639352-03-6.mol | [Molecular Weight]
1497.64 |
| Hazard Information | Back Directory | [Uses]
MC-VC-PABC-DNA31 is a agent-linker conjugate for ADC with potent antitumor activity by using DNA31 (a potent RNA polymerase inhibitor), linked via the ADC linker MC-VC-PABC. | [IC 50]
Traditional Cytotoxic Agents | [References]
[1] Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119. DOI:10.1038/nchem.2635 |
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