| Identification | Back Directory | [Name]
Tos-PEG2-CH2CO2tBu | [CAS]
1643957-24-7 | [Synonyms]
Tos-PEG1-CH2-Boc
Tos-PEG2-CH2CO2tBu
tert-Butyl 2-[2-(tosyloxy)ethoxy]acetate
Acetic acid, 2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C15H22O6S | [MDL Number]
MFCD28122953 | [MOL File]
1643957-24-7.mol | [Molecular Weight]
330.4 |
| Chemical Properties | Back Directory | [Boiling point ]
449.0±30.0 °C(Predicted) | [density ]
1.183±0.06 g/cm3(Predicted) | [storage temp. ]
Store at Room Tem. | [Appearance]
colorless liquid |
| Hazard Information | Back Directory | [Description]
Tos-PEG2-CH2CO2tBu is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions. | [Uses]
Tos-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6 |
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