| Identification | Back Directory | [Name]
OSMI-1 | [CAS]
1681056-61-0 | [Synonyms]
OSMI-1
OSMI-1 >=98% (HPLC)
Benzeneacetamide, α-[[(1,2-dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-, (αR)- | [Molecular Formula]
C28H25N3O6S2 | [MDL Number]
MFCD30187585 | [MOL File]
1681056-61-0.mol | [Molecular Weight]
563.64 |
| Chemical Properties | Back Directory | [density ]
1.389±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMF: 25 mg/mL; DMF:PBS (pH 7.2) (1:5): 0.16 mg/mL; DMSO: 20 mg/mL | [form ]
powder | [pka]
8.77±0.20(Predicted) | [color ]
white to beige | [InChIKey]
IYIGLWQQAMROOF-HHHXNRCGSA-N | [SMILES]
O=C(N1)C=CC2=C1C=CC(S(N[C@H](C3=C(OC)C=CC=C3)C(N(CC4=CC=CS4)CC5=CC=CO5)=O)(=O)=O)=C2 |
| Hazard Information | Back Directory | [Uses]
OSMI 1 is a novel inhibitor of O-GlcNAc transferase (OGT). | [Uses]
OSMI-1 (OGT with a small molecule inhibitor) has been used in proximal ligation assay, Sox2 (SRY (sex determining region Y)-Box 2 ) dual luciferase reporter assay, Sox2 ELISA (enzyme linked immunosorbent assay) and other in vivo approaches, to study the O-Linked β-N-acetylglucosamine (O-GlcNAc) mediated regulation of self-renewal genes in cancer. It has also been used to study the Hippo pathway regulation mediated by O-GlcNAc transferase. | [Definition]
ChEBI: OSMI-1 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 2-oxo-1,2-dihydroquinoline-6-sulfonic acid with the primary amino group of (2R)-2-amino-N-(2-furylmethyl)-2-(2-methoxyphenyl)-N-(2-thienylmethyl)acetamide. OSMI-1 is a cell permeable inhibitor of O-linked beta-N-acetylglucosamine transferase (O-GlcNAc transferase, OGT). It has a role as an EC 2.* (transferase) inhibitor and an EC 2.4.1.255 (protein O-GlcNAc transferase) inhibitor. It is a sulfonamide, a member of quinolines, a member of furans, a member of thiophenes, an aromatic ether and a tertiary carboxamide. | [Biochem/physiol Actions]
OGT catalyses the attachment of N-acetylglucosamine moieties to a number proteins during post-translational modification. Inhibition of OGT activity might hinder the rate of viral replication in infections such as Herpes simplex viral disease. | [in vivo]
Mammalian and zebrafish toxicity profiles are strikingly similar, and zebrafish can usually serve as an intermediate step between cell-based evaluation and conventional animal testing. The zebrafish model is used to investigate OSM1-1 acute toxicity in vivo. The LC50 of OSM1-1 is 0.031 mg/mL (56 μM, 12 h) and 0.025 mg/mL (45 μM, 24 h) in zebrafish model[2]. |
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Sigma-Aldrich
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021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
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400-0056266 |
| Website: |
www.energy-chemical.com |
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