| Identification | Back Directory | [Name]
Tetrazine-PEG5-NHS ester | [CAS]
1682653-80-0 | [Synonyms]
Tetrazine-PEG5-NHS ester
Tetrazine-Ph-PEG5-NHS ester
Tetrazine-PEG5-NHS ester >=95%
4,7,10,13,16-Pentaoxa-20-azaheneicosanoic acid, 19-oxo-21-[4-(1,2,4,5-tetrazin-3-yl)phenyl]-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C27H36N6O10 | [MDL Number]
MFCD28505547 | [MOL File]
1682653-80-0.mol | [Molecular Weight]
604.61 |
| Chemical Properties | Back Directory | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
powder or crystals | [pka]
14.28±0.46(Predicted) | [color ]
Purple to purplish red | [InChIKey]
DUPHIQYIPUTDJS-UHFFFAOYSA-N | [SMILES]
O=C(NCC1=CC=C(C2=NN=CN=N2)C=C1)CCOCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O |
| Hazard Information | Back Directory | [Description]
Tetrazine-PEG5-NHS Ester is a PEG linker containing a tetrazine group and an NHS ester which is very reactive with amine(NH2)-containing molecule. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene). | [Uses]
Tetrazine-PEG5-NHS ester (Tz-PEG5-NHS) can be used in click chemistry applications such as the preparation of chitosan-polyacrylamide microspheres utilizing selective tetrazine-trans-cyclooctene (Tz-TCO) ligation and the construction of copper-64 radiolabeled antibody by the click reaction. | [General Description]
Tetrazine-PEG5-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and tetrazine, which is reactive to trans-cyclooctenes. Hydrogen substituted tetrazines demonstrate exceptionally fast kinetics, generally at least 10-fold faster compared to methyl substituted tetrazines. The aqueous solubility of this reagent is substantially enhanced by a hydrophilic polyethylene glycol (PEG) spacer arm. | [reaction suitability]
reaction type: click chemistry
reagent type: linker | [IC 50]
PEGs; Alkyl/ether |
|
| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
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| Website: |
http://www.energy-chemical.com |
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