| Identification | Back Directory | [Name]
Tetrazine-PEG4-maleimide | [CAS]
1802908-02-6 | [Synonyms]
Tetrazine-PEG4-maleimide
Methyltetrazine-PEG4-maleimide
1H-Pyrrole-1-propanamide, 2,5-dihydro-N-[2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-2,5-dioxo-
3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-(2-(2-(2-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethyl)propanamide | [Molecular Formula]
C24H30N6O7 | [MDL Number]
MFCD28334552 | [MOL File]
1802908-02-6.mol | [Molecular Weight]
514.53 |
| Chemical Properties | Back Directory | [density ]
1.286±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Solid | [pka]
15.01±0.46(Predicted) | [color ]
Purple to purplish red |
| Hazard Information | Back Directory | [Description]
Methyltetrazine-PEG4-Maleimide is a click chemistry Maleimide linker. The maleimide group specifically and efficiently reacts with thiols to form thioether bond. This reagent can be used to efficieintly incorporate a tetrazine moiety with TCO-attached compound or macromolecule. | [Uses]
Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methyltetrazine-PEG4-maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|