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1683617-62-0

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1683617-62-0 Structure

1683617-62-0 Structure
IdentificationBack Directory
[Name]

Apcin-A
[CAS]

1683617-62-0
[Synonyms]

Apcin-A
ApcinA,Apcin A
[Molecular Formula]

C10H14Cl3N5O2
[MDL Number]

MFCD34469966
[MOL File]

1683617-62-0.mol
[Molecular Weight]

342.61
Chemical PropertiesBack Directory
[density ]

1.499±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 100 mg/mL (291.88 mM; Need ultrasonic)
[form ]

Solid
[pka]

9.84±0.46(Predicted)
[color ]

Off-white to yellow
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V (HY-130257)[1].
[References]

[1] Chi JJ, et al. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Oct 25. pii: S2352-3964(19)30677-2. DOI:10.1016/j.ebiom.2019.10.013
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