| Identification | Back Directory | [Name]
1,2-Propanedione, 1-[4-[4-[(4-chlorophenyl)amino]-6,7-dihydro-6-(1-methylethyl)-7-oxo-5H-pyrrolo[3,4-d]pyrimidin-2-yl]-1-piperazinyl]-, 2-oxime | [CAS]
169340-04-9 | [Synonyms]
ZM253270
ZM-253270
ZM 253270
1,2-Propanedione, 1-[4-[4-[(4-chlorophenyl)amino]-6,7-dihydro-6-(1-methylethyl)-7-oxo-5H-pyrrolo[3,4-d]pyrimidin-2-yl]-1-piperazinyl]-, 2-oxime | [Molecular Formula]
C22H26ClN7O3 | [MDL Number]
MFCD00943921 | [MOL File]
169340-04-9.mol | [Molecular Weight]
471.94 |
| Hazard Information | Back Directory | [Description]
ZM 253270 is a new class of nonpeptide neurokinin A antagonist. | [Uses]
ZM 253270 is a species-selective non-peptide NK-2 receptor (NK-2R) antagonist. ZM 253270 competitively inhibits the binding of [3H]NKA to native or cloned NK-2R from hamster bladder (Ki=2 nM), but has a weaker inhibitory effect (48-fold) on the binding of [3H]NKA to cloned human NK-2R[1]. | [IC 50]
Hamster Bladder NK-2: 2 nM (Ki) | [References]
[1] Aharony D, et al. Pharmacological characterization of a new class of nonpeptide neurokinin A antagonists that demonstrate species selectivity[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 274(3): 1216-1221. PMID:7562491 |
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