ChemicalBook--->CAS DataBase List--->1703768-74-4

1703768-74-4

1703768-74-4 Structure

1703768-74-4 Structure
IdentificationBack Directory
[Name]

Vipivotide tetraxetan Linker
[CAS]

1703768-74-4
[Synonyms]

PSMA-617 Linker
Vipivotide tetraxetan Linker
VIPIVOTIDE TETRAXETAN LINKER;PSMA-617 LINKER
L-Lysine, N6-[N-[[trans-4-(aminomethyl)cyclohexyl]carbonyl]-3-(2-naphthalenyl)-L-alanyl]-N2-[[[(1S)-1,3-dicarboxypropyl]amino]carbonyl]-
[Molecular Formula]

C33H45N5O9
[MDL Number]

MFCD32197316
[MOL File]

1703768-74-4.mol
[Molecular Weight]

655.74
Chemical PropertiesBack Directory
[Boiling point ]

1063.2±65.0 °C(Predicted)
[density ]

1.303±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

3.78±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Vipivotide tetraxetan Ligand-Linker Conjugate (PSMA-617 Ligand-Linker Conjugate) is a complex composed of pharmacophore group Glutamate-urea-Lysine peptide coupling linker, which can be used to synthesize Vipivotide tetraxetan (PSMA-617). Glutamate-urea-Lysine selectively binds to prostate-specific membrane antigen (PSMA)[1].
[IC 50]

Non-cleavable Linker
[References]

[1] Bene?ová M, et al. Albumin-Binding PSMA Ligands: Optimization of the Tissue Distribution Profile. Mol Pharm. 2018 Mar 5;15(3):934-946. DOI:10.1021/acs.molpharmaceut.7b00877
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