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2270986-66-6

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2270986-66-6 Structure

2270986-66-6 Structure
IdentificationBack Directory
[Name]

CL2 Linker
[CAS]

2270986-66-6
[Synonyms]

CL2 Linker
[Molecular Formula]

C68H103N11O22
[MDL Number]

MFCD32201141
[MOL File]

2270986-66-6.mol
[Molecular Weight]

1426.61
Chemical PropertiesBack Directory
[density ]

1.26±0.1 g/cm3(Predicted)
[pka]

12.65±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in agent substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2].
[IC 50]

Acid Cleavable Linker; Cleavable Linker
[References]

[1] Moon SJ, et al. Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy. J Med Chem. 2008 Nov 13;51(21):6916-26. DOI:10.1021/jm800719t
[2] Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69. DOI:10.1158/1078-0432.CCR-10-2939
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