| Identification | More | [Name]
4-Amino-3-chlorophenol | [CAS]
17609-80-2 | [Synonyms]
4-AMINO-3-CHLOROPHENOL
AMINO(4-)-3-CHLOROPHENOL
3-chloro-4-aminophenol
4-amino-3-chloro-pheno | [EINECS(EC#)]
241-583-3 | [Molecular Formula]
C6H6ClNO | [MDL Number]
MFCD00801116 | [Molecular Weight]
143.57 | [MOL File]
17609-80-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
159-160℃ | [Boiling point ]
287.3±25.0 °C(Predicted) | [density ]
1.406±0.06 g/cm3(Predicted) | [RTECS ]
SJ5710000 | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
9.26±0.18(Predicted) | [color ]
White | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C6H6ClNO/c7-5-3-4(9)1-2-6(5)8/h1-3,9H,8H2 | [InChIKey]
PNLPXABQLXSICH-UHFFFAOYSA-N | [SMILES]
C1(O)=CC=C(N)C(Cl)=C1 | [CAS DataBase Reference]
17609-80-2(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow solid | [Uses]
4-Amino-3-Chlorophenol acts as a synthetic reagent for the preparation of Benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer''s disease treatment. | [Application]
The 4-amino-3-chlorophenol is a crucial intermediate for preparing a tyrosine kinase inhibitor, tivozanib, and a late liver cancer drug, lenvatinib. As a crucial pharmaceutical chemical intermediate, 4-amino-3-chlorophenol is widely applied to the design and synthesis of medicaments for resisting tumors, cardiovascular diseases, neurological diseases, and the like. | [Synthesis]
Starting from o-chloronitrobenzene with the introduction of hydroxyl groups in the presence of strong acids and molybdenum salts as catalysts could synthesize 4-amino-3-chlorophenol. Beside, using m-chlorophenol as a starting material and introducing hydroxyl on a benzene ring through diazotization and coupling could synthesize 4-Amino-3-chlorophenol. |
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| Company Name: |
Nanjing Yiyuan Gold
|
| Telephone: |
18915107665 18061915908 |
| Website: |
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| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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