| Identification | More | [Name]
1-Cyclohexylpiperazine | [CAS]
17766-28-8 | [Synonyms]
1-CYCLOHEXYLPIPERAZINE
AKOS BBS-00003612
BUTTPARK 82\06-06
TIMTEC-BB SBB003875
N-Cyclohexylpiperazine
1-CYCLOHEXYL-PIPERAZINE >98%
1-CYCLOHEXYLPIPERAZINE 98%
1-Cyclohexylpiperizine
Piperazine, 1-cyclohexyl- | [EINECS(EC#)]
241-750-0 | [Molecular Formula]
C10H20N2 | [MDL Number]
MFCD00044809 | [Molecular Weight]
168.28 | [MOL File]
17766-28-8.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow-brownish low melting solid | [Melting point ]
28-32 °C
| [Boiling point ]
287.25°C (rough estimate) | [density ]
0.9725 (rough estimate) | [refractive index ]
1.6011
| [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Low Melting Solid | [pka]
9.25±0.10(Predicted) | [color ]
Yellow-brownish | [Detection Methods]
GC | [BRN ]
106845 | [InChI]
InChI=1S/C10H20N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h10-11H,1-9H2 | [InChIKey]
XPDSXKIDJNKIQY-UHFFFAOYSA-N | [SMILES]
N1(C2CCCCC2)CCNCC1 | [CAS DataBase Reference]
17766-28-8(CAS DataBase Reference) | [Storage Precautions]
Store under inert gas |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HS Code ]
29335990 |
| Hazard Information | Back Directory | [Chemical Properties]
yellow-brownish low melting solid | [Uses]
1-Cyclohexylpiperazine is an σ1 and σ2 receptor ligands with diagnostic and therapeutic potentials. | [Synthesis Reference(s)]
Tetrahedron Letters, 35, p. 7331, 1994 DOI: 10.1016/0040-4039(94)85306-1 | [Materials Uses]
1-Cyclohexylpiperazine can be used to develop new luminescent materials such as [CYP]ZnBr4 (CYP = 1-cyclohexylpiperazine). It is a highly efficient blue luminescent lead-free halide material with high luminous efficiency (photoluminescence quantum yield up to 79.22%) and stability, which can be used to manufacture highly efficient blue phosphors for white light-emitting diodes (LEDs) [1]. | [Synthesis]
General procedure for the synthesis of 1-cyclohexylpiperazine from tert-butyl 4-cyclohexylpiperazine-1-carboxylate: tert-butyl 4-cyclohexylpiperazine-1-carboxylate (1.38 g, 5.15 mmol) was dissolved in a mixture of ethanol/hydrochloric acid (15 mL), and the reaction was stirred for 18 h at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. To the residue, 5 mL of water was added and the aqueous phase was washed with ethyl acetate (5 mL × 3). Subsequently, the aqueous phase was adjusted to pH 7~8 with base and extracted with ethyl acetate (10 mL × 3). All organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 0.78 g of 1-cyclohexylpiperazine (confirmed by LC-MS and TLC, yield: 90.1%). | [References]
[1] Wang, Yu-Yin et al. “High Emission Efficiency and Thermal Stability in Zero-Dimensional Hybrid Zinc Halide as a Blue Light Emitter.” Inorganic chemistry vol. 62,38 (2023): 15711-15718. doi:10.1021/acs.inorgchem.3c02313 |
|
|