| Identification | Back Directory | [Name]
Pyridine, 4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-, hydrochloride (1:1) | [CAS]
1781834-82-9 | [Synonyms]
Pyridine, 4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-, hydrochloride (1:1) | [Molecular Formula]
C17H24ClN3O | [MOL File]
1781834-82-9.mol | [Molecular Weight]
321.85 |
| Hazard Information | Back Directory | [Description]
PSN 375963 hydrochloride is a GPR119 receptor agonist | [Uses]
PSN 375963 hydrochloride is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 hydrochloride shows similar potency to the endogenous agonist oleoylethanolamide (OEA)[1][2]. | [References]
[1] Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3(3):167-175. DOI:10.1016/j.cmet.2006.02.004
[2] Ning Y, et al. Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br J Pharmacol. 2008;155(7):1056-1065. DOI:10.1038/bjp.2008.337 |
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