| Identification | Back Directory | [Name]
ADIPORON HYDROCHLORIDE | [CAS]
1781835-20-8 | [Synonyms]
ADIPORON HYDROCHLORIDE
2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide hydrochloride | [Molecular Formula]
C27H29ClN2O3 | [MDL Number]
MFCD27991295 | [MOL File]
1781835-20-8.mol | [Molecular Weight]
464.99 |
| Hazard Information | Back Directory | [Uses]
AdipoRon Hydrochloride is the hydrochloride salt of AdipoRon (A291670), which is an AdipoR agonist and activates AMPK and PPAR-α pathways in the muscle and liver. AdipoRon is a promising therapeutic approach for the treatment of obesity-related diseases such as type 2 diabetes. | [in vivo]
AdipoRon (50 mg/kg, i.v.) cuases significant phosphorylation of AMPK in skeletal muscle and liver of wild-type mice but not Adipor1 / Adipor2 / double-knockout mice[1]. AdipoRon (0.02, 0.1, and 0.5 mg/kg, i.g.) alleviates D-GalN induced hepatotoxicity in mice, and prevents hepatic architecture distortion against D-GalN challenge. The hepatoprotective potential of AdipoRon is particularly evident in higher dosages (0.1 and 0.5 mg/kg)[2]. Enhanced cardiomyocyte apoptosis in APN-deficient mice is rescued by AdipoRon (50 mg/kg, p.o.) administration. Antiapoptotic effect of AdipoRon is attenuated but not lost in AMPK-DN mice[3]. | [storage]
Store at -20°C |
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