| Identification | Back Directory | [Name]
GL67 | [CAS]
179075-30-0 | [Synonyms]
GL67
GL67 HCl form
N4-Cholesteryl-Spermine HCl Salt
5-allyl-5'-(2,3-dihydroxypropyl)-[1,1'-biphenyl]-2,2'-diol
Cholest-5-en-3-ol (3β)-, 3-[(3-aminopropyl)[4-[(3-aminopropyl)amino]butyl]carbamate] | [Molecular Formula]
C38H70N4O2 | [MOL File]
179075-30-0.mol | [Molecular Weight]
615 |
| Chemical Properties | Back Directory | [Boiling point ]
690.9±55.0 °C(Predicted) | [density ]
1.03±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: Sparingly Soluble: 1-10 mg/ml | [form ]
powder | [pka]
10.54±0.19(Predicted) | [InChIKey]
KBBLYWGVXTZWCU-JPEXWTJSSA-N | [SMILES]
CC1(CC[C@H](OC(N(CCCN)CCCCNCCCN)=O)C2)C2=CCC3C1CCC4(C)C3CCC4C(CCCC(C)C)C |
| Hazard Information | Back Directory | [Uses]
GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection[1]. | [Biological Activity]
N4-Cholesteryl-Spermine (GL67) in combination with DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) and DMPE-PEG5000 (1,2-Dimyristoyl-sn-Glycero-3-Phosphoethanolamine-N-[methoxy (Polyethylene glycol)5000] is used as a non-viral gene transfer agent. | [References]
[1] Andries O, et al. Comparison of the gene transfer efficiency of mRNA/GL67 and pDNA/GL67 complexes in respiratory cells. Mol Pharm. 2012 Aug 6;9(8):2136-45. DOI:10.1021/mp200604h |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|