| Identification | Back Directory | [Name]
HaloPROTAC 2 | [CAS]
1799506-06-1 | [Synonyms]
HaloPROTAC 2
L-Prolinamide, N-(21-chloro-1-oxo-3,6,9,12,15-pentaoxaheneicos-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- | [Molecular Formula]
C38H59ClN4O9S | [MDL Number]
MFCD31692393 | [MOL File]
1799506-06-1.mol | [Molecular Weight]
783.41 |
| Chemical Properties | Back Directory | [Boiling point ]
940.5±65.0 °C(Predicted) | [density ]
1.200±0.06 g/cm3(Predicted) | [storage temp. ]
-80°C, protect from light, stored under nitrogen | [solubility ]
DMSO : ≥ 50 mg/mL (63.82 mM) | [form ]
Viscous Liquid | [pka]
13.54±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
HaloPROTAC2 is a novel HaloPROTAC degrader, inducing degradation of HaloTag fusion proteins. | [Uses]
VH032-PEG5-C6-Cl (HaloPROTAC 2) is a conjugate of ligands for E3 and 21-atom-length linker. The connector of linker is Halogen group. VH032-PEG5-C6-Cl incorporates the VH032 based VHL ligand and 5-unit PEG linker. VH032-PEG5-C6-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1]. | [IC 50]
VHL | [storage]
-80°C, protect from light, stored under nitrogen | [References]
[1] Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7. DOI:10.1021/acschembio.5b00442 |
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