| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2306193-99-5 | [Synonyms]
VH 101, phenol
Phenolic VH101
E3 ligase Ligand 19
VH032-cyclopropane-F
(2S,4R)-1-((S)-2-(1-fluorocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
(2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | [Molecular Formula]
C26H33FN4O5S | [MDL Number]
MFCD32201089 | [MOL File]
2306193-99-5.mol | [Molecular Weight]
532.63 |
| Chemical Properties | Back Directory | [Boiling point ]
841.7±65.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.12±0.35(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
VH032-cyclopropane-F (VH 101, phenol) is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal hydroxyl group. Allows rapid conjugation with many linkers containing active leaving groups. A basic building block for development of a protein degrader library.
| [reaction suitability]
reagent type: ligand | [IC 50]
VHL | [storage]
Store at +4°C |
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