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2376990-26-8

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2376990-26-8 Structure

2376990-26-8 Structure
IdentificationBack Directory
[Name]

VH 032 phenol-linker 1
[CAS]

2376990-26-8
[Synonyms]

VH 032 phenol-linker 1
VH 032 phenol-alkylC4-amine
(S,R,S)-AHPC-phenol-C4-NH2 (dihydrochloride)
[Molecular Formula]

C28H42ClN5O5S
[MOL File]

2376990-26-8.mol
[Molecular Weight]

596.18
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

(S,R,S)-AHPC-phenol-C4-NH2 (VH032-phenol-C4-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC?based VHL ligand and a linker used in?PROTAC?technology[1].
[storage]

Store at -20°C
[References]

[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery.?Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] [3].Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
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