| Identification | Back Directory | [Name]
AZ044 | [CAS]
1800017-49-5 | [Synonyms]
AZ044
SB19683
Cyclohexanecarboxylic acid, 4-[[[6-[1-(cyclopropylmethyl)-1,2-dihydro-2-oxo-4-pyridinyl]-2-benzothiazolyl]amino]methyl]-, trans-
(1r,4r)-4-(((6-(1-(Cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)methyl)cyclohexane-1-carboxylic acid | [Molecular Formula]
C24H27N3O3S | [MDL Number]
MFCD30718008 | [MOL File]
1800017-49-5.mol | [Molecular Weight]
437.55 |
| Hazard Information | Back Directory | [Description]
AZ044 is a novel potent, selective inhibitor of alpha-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIalpha). | [Uses]
PI4K-IN-1 (compound 44) is a potent PI4KIII inhibitor, with pIC50 values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively. PI4K-IN-1 also inhibits PI3Kα/β/γ/δ, with pIC50 values of 4.0/<3.7/5.0/<4.1, respectively[1]. | [IC 50]
PI4KIIIα: 9.0 (pIC50); PI4KIIIβ: 6.6 (pIC50); PI3Kα: 4.0 (pIC50); PI3Kβ: <3.7 (pIC50); PI3Kγ: 5.0 (pIC50); PI3Kδ: <4.1 (pIC50) | [References]
[1] Raubo P, et al. Discovery of potent, selective small molecule inhibitors of α-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIα). Bioorg Med Chem Lett. 2015 Aug 15;25(16):3189-93. DOI:10.1016/j.bmcl.2015.05.093 |
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| Company Name: |
Elucigen bio
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| Tel: |
13501719342; 13501719342 |
| Website: |
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