| Identification | Back Directory | [Name]
KL-1333 | [CAS]
1800405-30-4 | [Synonyms]
KL-1333
NQO1 ACTIVATOR 1
KL-1333(NQO1 activator 1)
2-(1-Methylethyl)-3H-naphth[1,2-d]imidazole-4,5-dione
3H-Naphth[1,2-d]imidazole-4,5-dione, 2-(1-methylethyl)- | [Molecular Formula]
C14H12N2O2 | [MOL File]
1800405-30-4.mol | [Molecular Weight]
240.26 |
| Chemical Properties | Back Directory | [Boiling point ]
517.3±19.0 °C(Predicted) | [density ]
1.329±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (1040.54 mM) | [form ]
Solid | [pka]
8.58±0.20(Predicted) | [color ]
Reddish brown to red | [InChI]
InChI=1S/C14H12N2O2/c1-7(2)14-15-10-8-5-3-4-6-9(8)12(17)13(18)11(10)16-14/h3-7H,1-2H3,(H,15,16) | [InChIKey]
AJFWITSBVLLDCC-UHFFFAOYSA-N | [SMILES]
C1(C(C)C)NC2C(=O)C(=O)C3=C(C=2N=1)C=CC=C3 |
| Hazard Information | Back Directory | [Uses]
KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures[1][2]. | [storage]
Store at -20°C | [References]
[1] Seo KS, et al. KL1333, a Novel NAD+ Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts. Front Neurol. 2018;9:552. Published 2018 Jul 5. DOI:10.3389/fneur.2018.00552
[2] Lee HS, et al. KL1333, a derivative of β-lapachone, protects against cisplatin-induced ototoxicity in mouse cochlear cultures. Biomed Pharmacother. 2020;126:110068. DOI:10.1016/j.biopha.2020.110068 |
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