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1802078-33-6

1802078-33-6 Structure

1802078-33-6 Structure
IdentificationBack Directory
[Name]

Mca-Amyloid β/A4 Protein Precursor770(667-676)-Lys(Dnp)-Arg-Arg amide trifluoroacetate salt
[CAS]

1802078-33-6
[Synonyms]

Mca-Amyloid β/A4 Protein Precursor770 (667-676)-Lys(Dnp)-Arg-Arg amide
Mca-Amyloid β/A4 Protein Precursor770(667-676)-Lys(Dnp)-Arg-Arg amide trifluoroacetate salt
Mca-Amyloid β/A4 Protein Precursor??? (667-676)-Lys(Dnp)-Arg-Arg amide trifluoroacetate salt
L-Argininamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-lysyl-L-methionyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysyl-L-arginyl-
[Molecular Formula]

C87H129N27O28S
[MDL Number]

MFCD31692277
[MOL File]

1802078-33-6.mol
[Molecular Weight]

2033.21
Chemical PropertiesBack Directory
[density ]

1.52±0.1 g/cm3(Predicted)
[pka]

4.19±0.10(Predicted)
[Sequence]

{Mca}-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-{Lys(Dnp)}-Arg-Arg-NH2
Hazard InformationBack Directory
[Uses]

Mca-SEVKMDAEFRK(Dnp)RR-NH2, containing the wild-type amyloid precursor protein (APP) beta-secretase cleavage site, is the substrate of thimet oligopeptidase (TOP). It is used for Alzheimer's disease research[1].
[References]

[1] H Koike, et al. Thimet Oligopeptidase Cleaves the Full-Length Alzheimer Amyloid Precursor Protein at a β-Secretase Cleavage Site in COS Cells. J Biochem. 1999 Jul;126(1):235-42. DOI:10.1093/oxfordjournals.jbchem.a022428
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