| Identification | Back Directory | [Name]
Methyltetrazine-PEG4-Acid | [CAS]
1802907-91-0 | [Synonyms]
Methyltetrazine-PEG4-Acid
Methyltetrazine-PEG4-COOH
Methyltetrazine-PEG4-COOH,Methyltetrazine-PEG4-Acid
1-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy)-3,6,9,12-tetraoxapentadecan-15-oic acid
3-(2-(2-(2-(2-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethoxy)propanoic acid
Propanoic acid, 3-[2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethoxy]- | [Molecular Formula]
C20H28N4O7 | [MDL Number]
MFCD28334558 | [MOL File]
1802907-91-0.mol | [Molecular Weight]
436.46 |
| Chemical Properties | Back Directory | [Boiling point ]
647.6±65.0 °C(Predicted) | [density ]
1.236±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DMF, DCM | [form ]
Solid | [pka]
4.28±0.10(Predicted) | [color ]
Purple to purplish red |
| Hazard Information | Back Directory | [Description]
Methyltetrazine-PEG4-Acid is a stable tetrazines molecule containing a terminal carboxylic acid (CO2H) The terminal acid can react with primary amine groups in the presence of of activators (e.g. EDC, or HATU) to form a stable amide bond. Methyltetrazine enable fast click chemistry with TCO ((trans-cycloctene), methyl group enhances the stability of tetrazine moiety. | [Uses]
Methyltetrazine-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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