| Identification | Back Directory | [Name]
Methyltetrazine-PEG5-Alkyne | [CAS]
1802907-97-6 | [Synonyms]
Methyltetrazine-PEG5-Alkyne
3-(4-(3,6,9,12-Tetraoxapentadec-14-yn-1-yloxy)phenyl)-6-methyl-1,2,4,5-tetrazine
1,2,4,5-Tetrazine, 3-methyl-6-[4-(3,6,9,12-tetraoxapentadec-14-yn-1-yloxy)phenyl]- | [Molecular Formula]
C20H26N4O5 | [MDL Number]
MFCD28334550 | [MOL File]
1802907-97-6.mol | [Molecular Weight]
402.44 |
| Chemical Properties | Back Directory | [Boiling point ]
568.5±60.0 °C(Predicted) | [density ]
1.176±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, stored under nitrogen | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Solid | [pka]
1.67±0.10(Predicted) | [color ]
Pink to red |
| Hazard Information | Back Directory | [Description]
Methyltetrazine-PEG5-alkyne is a click chemistry bifunctional molecule containing an alkyne group and a hydrophilic PEG spacer which increases water-solubility. This reagent enables simple and efficient incorporation of a tetrazine moiety onto TCO-attached antibodies, peptide or other biomolecule The alkynes can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. | [Uses]
Methyltetrazine-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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