| Identification | Back Directory | [Name]
Azido-dPEG4-acid | [CAS]
1056024-94-2 | [Synonyms]
N3-PEG3-COOH
Azido-dPEG4-acid
N3-PEG3-CH2CH2COOH
N3-PEG3-COOH,Azido-PEG3-acid
N3-(CH2)2-O-(CH2-CH2-O)2-(CH2)2-COOH | [Molecular Formula]
C9H17N3O5 | [MDL Number]
MFCD23726617 | [MOL File]
1056024-94-2.mol | [Molecular Weight]
247.25 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C, protect from light | [solubility ]
DMSO : 100 mg/mL (404.45 mM; Need ultrasonic) | [form ]
Liquid | [color ]
Colorless to light yellow | [Appearance]
colorless liquid | [InChI]
InChI=1S/C9H17N3O5/c10-12-11-2-4-16-6-8-17-7-5-15-3-1-9(13)14/h1-8H2,(H,13,14) | [InChIKey]
VWJGWKZZFZMGGY-UHFFFAOYSA-N | [SMILES]
O(CCOCCC(=O)O)CCOCCN=[N+]=[N-] |
| Hazard Information | Back Directory | [Description]
Azido-PEG3-acid is a crosslinker containing an azide(N3) group with a carboxylic acid (CO2H). The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. | [Definition]
ChEBI: 3-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}propanoic acid is an organonitrogen compound. | [Biological Activity]
Azido-dPEG4-acid is a PEG-based PROTAC linker for the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. It is also a non-cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
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| Company Name: |
T&W GROUP
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| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
| Company Name: |
Borenpharm Co., Ltd
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| Telephone: |
027-65563561 13026317987; |
| Website: |
http://www.borenpharm.com |
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