| Identification | Back Directory | [Name]
Dde Biotin-PEG4-DBCO | [CAS]
1807512-43-1 | [Synonyms]
CAS_1807512-43-1
Dde Biotin-PEG4-DBCO | [Molecular Formula]
C47H61N5O9S | [MDL Number]
MFCD28505548 | [MOL File]
1807512-43-1.mol | [Molecular Weight]
872.09 |
| Hazard Information | Back Directory | [Description]
Dde Biotin-PEG4-DBCO is a cleavable biotin reagent that is reactive with azide moiety via copper-free Click Chemistry. Dde protecting group allows efficient release of captured biotinylated molecules from streptavidin under mild conditions with hydrazine. | [Uses]
Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Dde Biotin-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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