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1807512-43-1

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1807512-43-1 Structure

1807512-43-1 Structure
IdentificationBack Directory
[Name]

Dde Biotin-PEG4-DBCO
[CAS]

1807512-43-1
[Synonyms]

CAS_1807512-43-1
Dde Biotin-PEG4-DBCO
[Molecular Formula]

C47H61N5O9S
[MDL Number]

MFCD28505548
[MOL File]

1807512-43-1.mol
[Molecular Weight]

872.09
Chemical PropertiesBack Directory
[Boiling point ]

1103.9±65.0 °C(Predicted)
[density ]

1.29±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

13.90±0.40(Predicted)
Hazard InformationBack Directory
[Description]

Dde Biotin-PEG4-DBCO is a cleavable biotin reagent that is reactive with azide moiety via copper-free Click Chemistry. Dde protecting group allows efficient release of captured biotinylated molecules from streptavidin under mild conditions with hydrazine.
[Uses]

Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Dde Biotin-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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