| Identification | Back Directory | [Name]
Mal-PEG1-NHS ester | [CAS]
1807518-72-4 | [Synonyms]
Mal-PEG1-SPA
CAS_1807518-72-4
Mal-PEG1-NHS ester
2,5-Dioxopyrrolidin-1-yl 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoate
Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C13H14N2O7 | [MDL Number]
MFCD26127783 | [MOL File]
1807518-72-4.mol | [Molecular Weight]
310.26 |
| Chemical Properties | Back Directory | [Boiling point ]
488.4±55.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DCM | [form ]
Solid | [pka]
-2.35±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Mal-PEG1-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | [Biological Activity]
Mal-PEG1-NHS ester is a cleavable PEG-based ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PEG-based PROTAC linker that can be used to synthesize PROTACs. | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
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T&W GROUP
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Tags:1807518-72-4
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