1807530-08-0

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1807530-08-0 Structure

Identification	Back Directory
[Name] Mal-PEG1-PFP
[CAS] 1807530-08-0
[Synonyms] Mal-PEG1-PFP Mal-PEG1-PFP ester Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-, 2,3,4,5,6-pentafluorophenyl ester
[Molecular Formula] C15H10F5NO5
[MDL Number] MFCD26127800
[MOL File] 1807530-08-0.mol
[Molecular Weight] 379.24

Chemical Properties	Back Directory
[Boiling point ] 452.8±45.0 °C(Predicted)
[density ] 1.541±0.06 g/cm3(Predicted)
[solubility ] Soluble in DCM
[pka] -2.34±0.20(Predicted)

Hazard Information	Back Directory
[Description] Mal-PEG1-PFP is a PEG linker containing maleimide and PFP moieties. Maleimides are thiol-reactive and react between pH 6.5 and 7.5 to form thiolester bonds. PFP moieties are amine-reactive and are less susceptible to undergo hydrolysis. The hydrophilic PEG linker increases the water solubility of a compound in aqueous media.
[Uses] Mal-PEG1-PFP ester is a Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
[IC 50] Alkyl/ether

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