| Identification | Back Directory | [Name]
Mal-PEG4-NHS ester | [CAS]
1325208-25-0 | [Synonyms]
Mal-PEG4-NHS ester
2，5-dioxopyrrolidin-1-yl1-(2，5-dioxo-2H-pyrrol-1(5H)-yl)-3，6，9，12-tetraoxapentadecan-15-oate
4,7,10,13-Tetraoxapentadecanoic acid, 15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C19H26N2O10 | [MDL Number]
MFCD20230464 | [MOL File]
1325208-25-0.mol | [Molecular Weight]
442.42 |
| Chemical Properties | Back Directory | [Boiling point ]
580.5±60.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Soluble in DCM | [form ]
Solid-Liquid Mixture | [pka]
-2.34±0.20(Predicted) | [color ]
Off-white to yellow | [InChI]
InChI=1S/C19H26N2O10/c22-15-1-2-16(23)20(15)6-8-28-10-12-30-14-13-29-11-9-27-7-5-19(26)31-21-17(24)3-4-18(21)25/h1-2H,3-14H2 | [InChIKey]
TUPOSLKVPPFQGR-UHFFFAOYSA-N | [SMILES]
C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCN1C(=O)C=CC1=O |
| Hazard Information | Back Directory | [Description]
Mal-PEG4-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | [Uses]
Mal-PEG4-NHS ester is a non-cleavable ADC linker which links Quantum dots (QDs) with PEGylated liposomes[1]. | [IC 50]
Non-cleavable Linker | [References]
[1] Mukthavaram R, et al. Assembly and targeting of liposomal nanoparticles encapsulating quantum dots. Bioconjug Chem. 2011;22(8):1638-1644. DOI:10.1021/bc200201e |
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