| Identification | Back Directory | [Name]
Fluorescein-PEG4-Acid | [CAS]
1807518-76-8 | [Synonyms]
5-FITC-PEG4-COOH
Flurescein-PEG4-COOH
Fluorescein-PEG4-Acid | [Molecular Formula]
C32H34N2O11S | [MDL Number]
MFCD23726637 | [MOL File]
1807518-76-8.mol | [Molecular Weight]
654.68 |
| Chemical Properties | Back Directory | [Boiling point ]
873.4±75.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DMF, DCM | [pka]
4.28±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Fluorescein-PEG4-Acid is a xanthene dye with excitation/emmission maximum 494/517 nm and a free terminal carboxyl acid. Terminal carboxylic acid can react with primary amine groups in the presence of of activators (e.g. EDC, or HATU) to form a stable amide bond. It be used as quantum yield standard. Hydophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. | [Uses]
Fluorescein-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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Alfa Chemistry
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https://www.alfa-chemistry.com |
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Shanghai Uchem Inc.
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15618758386 15618758386 |
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https://www.chemicalbook.com/ShowSupplierProductsList15300/0_EN.htm |
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