| Identification | Back Directory | [Name]
FAM alkyne, 5-isomer | [CAS]
510758-19-7 | [Synonyms]
FAM alkyne, 5-isomer
FAMalkyne,5-isomer, >97%
3',6'-Dihydroxy-3-oxo-N-(prop-2-yn-1-yl)-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxamide
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxamide, 3',6'-dihydroxy-3-oxo-N-2-propyn-1-yl- | [Molecular Formula]
C24H15NO6 | [MDL Number]
MFCD28505571 | [MOL File]
510758-19-7.mol | [Molecular Weight]
413.38 |
| Chemical Properties | Back Directory | [Melting point ]
313 °C(dec.) | [Boiling point ]
709.6±60.0 °C(Predicted) | [density ]
1.58±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
Soluble in DMSO, DMF, DCM | [form ]
powder to crystal | [pka]
9.32±0.20(Predicted) | [color ]
Light yellow to Yellow to Orange | [Appearance]
yellow solid |
| Hazard Information | Back Directory | [Description]
FAM (fluorescein) alkyne is a high purity (95%) 5-isomer with significant aqueous solubility. Alkyne enables copper-catalyzed Click chemistry. | [Uses]
5-FAM-Alkyne is a high selective and sensitive fluorescent biosensor for alkaline phosphatase (ALP)[1]. 5-FAM-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Mengmeng Zhao, et al. A Sensitive Fluorescence Biosensor for Alkaline Phosphatase Activity Based on the Cu(II)-dependent DNAzyme. Anal Chim Acta. 2016 Dec 15;948:98-103. DOI:10.1016/j.aca.2016.10.033 | [Abs/Em Maxima]
492/517 nm | [Fluoresene quantum yield]
0.93 | [Extinction Coefficient]
74000 | [CF260]
0.22 | [CF280]
0.17 |
|
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