| Identification | Back Directory | [Name]
Mal-PEG1-Bromide | [CAS]
1823885-81-9 | [Synonyms]
Mal-PEG1-Bromide
1H-Pyrrole-2,5-dione, 1-[2-(2-bromoethoxy)ethyl]- | [Molecular Formula]
C8H10BrNO3 | [MDL Number]
MFCD28015775 | [MOL File]
1823885-81-9.mol | [Molecular Weight]
248.07 |
| Chemical Properties | Back Directory | [Boiling point ]
358.1±22.0 °C(Predicted) | [density ]
1.588±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [pka]
-2.35±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
Mal-PEG1-Bromide contains a maleimide group and bromide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. | [Uses]
Mal-PEG1-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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