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1807639-36-6

1807639-36-6 Structure

1807639-36-6 Structure
IdentificationBack Directory
[Name]

FX12
[CAS]

1807639-36-6
[Synonyms]

[Molecular Formula]

C10H8O4S
[MOL File]

1807639-36-6.mol
[Molecular Weight]

224.23
Chemical PropertiesBack Directory
[Boiling point ]

436.264±45.00 °C(Press: 760.00 Torr)(predicted)
[density ]

1.456±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[solubility ]

Acetonitrile: Slightly soluble: 0.1-1 mg/ml
DMSO: Sparingly soluble: 1-10 mg/ml
Hazard InformationBack Directory
[Uses]

RNF5-IN-1 (FX12) is a selective RNF5 degrader. RNF5-IN-1 binds to RNF5 and inhibits its E3 activity, and promotes proteasomal degradation of RNF5 in an endoplasmic reticulum (ER)-associated degradation (ERAD) way in cells. RNF5-IN-1 inhibits α-1-antitrypsin (NHK) dislocation with an IC50 value of 2.7 μM. RNF5-IN-1 can be used for research of cystic fibrosis, acute myeloid leukemia, and certain viral infections[1].
[References]

[1] Ruan J, et al. A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase. Mol Biol Cell. 2022 Nov 1;33(13):ar120. DOI:10.1091/mbc.E22-06-0233
1807639-36-6 suppliers list
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Website: www.caymanchem.com
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