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18097-52-4

18097-52-4 Structure

18097-52-4 Structure
IdentificationBack Directory
[Name]

2-AMINO-5-CHLOROBENZOPHENONE OXIME
[CAS]

18097-52-4
[Synonyms]

AKOS 90376
TIMTEC-BB SBB003174
Mixtureofsyn-andanti-isomeres
2-Amino-5-Chlorobenzopheone Oxime
2-AMINO-5-CHLOROBENZOPHENONE OXIME
2-AMINO-5-CHLOROBENZOPHENEONE OXIME
2-Amino-5-chlorobenzophenoneα-oxime-,(Z)-
(2-amino-5-chlorophenyl)phenyl-methanonoxime
Methanone,(2-amino-5-chlorophenyl)phenyl-,oxime
2-amino-5-chlorobenzophenoneoxime,mixtureofsynandantiisomers
2-AMINO-5-CHLOROBENZOPHENONE OXIME, 98%, MIXTURE OF SYN AND ANTI ISOMERS
[EINECS(EC#)]

241-999-5
[Molecular Formula]

C13H11ClN2O
[MDL Number]

MFCD00014780
[MOL File]

18097-52-4.mol
[Molecular Weight]

246.69
Chemical PropertiesBack Directory
[Appearance]

yellow crystalline powder
[Melting point ]

117-120oC
[Boiling point ]

434.9±45.0 °C(Predicted)
[density ]

1.27±0.1 g/cm3(Predicted)
[storage temp. ]

Hygroscopic, -20°C Freezer, Under inert atmosphere
[solubility ]

Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
[form ]

Solid
[pka]

10.20±0.28(Predicted)
[color ]

Pale Yellow to Light Yellow
[EPA Substance Registry System]

Methanone, (2-amino-5-chlorophenyl)phenyl-, oxime (18097-52-4)
Hazard InformationBack Directory
[Chemical Properties]

yellow crystalline powder
[Uses]

Intermediate in the preparation of Chlordiazepoxide (C327050) and its metabolites.
[Definition]

ChEBI: (2-amino-5-chlorophenyl)(phenyl)methanone oxime is a diarylmethane.
[Synthesis Reference(s)]

The Journal of Organic Chemistry, 30, p. 3957, 1965 DOI: 10.1021/jo01022a519
Safety DataBack Directory
[Safety Statements ]

24/25
[TSCA ]

TSCA listed
[REACH Registrations]

Active
[HS Code ]

29280090
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Hydroxylamine hydrochloride-->Water-->2-Amino-5-chlorobenzophenone-->Isoxazole
[Preparation Products]

7-chloro-1,3-dihydro-5-phenyl-2-oxo-2H-1,4-benzodiazepin-3-yl acetate-->6-Chloro-2-(chloromethyl)-3-oxido-4-phenyl-quinazoline-->Demoxepam-->Chlordiazepoxide
Questions And AnswerBack Directory
[Description]

2-Amino-5-Chlorobenzophenone is in the form of a yellow-brown crystalline powder. Its melting point is 98-100°C. It is used to produce intermediates for the synthesis of Oxazolam drug and intermediates for psychotherapeutic agents, such as chlorodiazepoxide and diazepam.1,2
[Reference]

  1. R. Liao, Synthetic method of Oxazolam drug intermediate 2-amino-5-chlorobenzophenone, Patent CN105461576A
  2. S. Nakanishi, W. E. Barth, Process for preparing 6-chloromethyl-4-phenylquinazoline-3-oxide and intermediates therefor, Patent US3932325A
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