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1810869-23-8

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1810869-23-8 Structure

1810869-23-8 Structure
IdentificationBack Directory
[Name]

2-Chloro-7-(2-deoxy-4-C-ethynyl-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
[CAS]

1810869-23-8
[Synonyms]

2-Chloro-7-(2-deoxy-4-C-ethynyl-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 2-chloro-7-(2-deoxy-4-C-ethynyl-β-D-erythro-pentofuranosyl)-
[Molecular Formula]

C13H13ClN4O3
[MOL File]

1810869-23-8.mol
[Molecular Weight]

308.72
Chemical PropertiesBack Directory
[density ]

1.63±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[pka]

12.67±0.60(predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

MK-8527 is an orally active HIV inhibitor and nucleoside reverse transcriptase translocation inhibitor (NRTTI) with antiviral activity. MK-8527 has a similar inhibitory mechanism to ISL (HY-104012)[1][2][3][4].
[References]

[1] Gillespie SW, et al. Islatravir: evaluation of clinical development for HIV and HBV. Expert Opin Investig Drugs. 2024 Feb;33(2):85-93. DOI:10.1080/13543784.2024.2305130
[2] Liu AY, et al. CROI 2024: Global Epidemiology and Prevention of HIV and Other Sexually Transmitted Diseases. Top Antivir Med. 2024 Jul 17;32(3):447-482. PMID:39142289
[3] Gunaratne SH, et al. CROI 2024: The Challenges of Sustained Viral Suppression, Advanced HIV Disease, and Ending the HIV Epidemic Targets. Top Antivir Med. 2024 Aug 12;32(4):542-567. PMID:39746674
[4] Zhernov YV, et al. Microbicides for Topical HIV Immunoprophylaxis: Current Status and Future Prospects. Pharmaceuticals (Basel). 2024 May 22;17(6):668. DOI:10.3390/ph17060668
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