| Identification | Back Directory | [Name]
1,1,1-Trifluoroethyl-PEG5-Propargyl | [CAS]
1817735-37-7 | [Synonyms]
1,1,1-Trifluoroethyl-PEG5-Propargyl
1,1,1-Trifluoroethyl-PEG4-propargyl | [Molecular Formula]
C13H21F3O5 | [MDL Number]
MFCD29042360 | [MOL File]
1817735-37-7.mol | [Molecular Weight]
314.298 |
| Hazard Information | Back Directory | [Description]
1,1,1-Trifluoroethyl-PEG5-Propargyl forms triazole linkage with azides via copper catalyzed azide-alkyne Click Chemistry. The trifluoroethyl group is reactive towards primary amine groups in proteins, antibody and other molecules and surfaces. | [Uses]
1,1,1-Trifluoroethyl-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 1,1,1-Trifluoroethyl-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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