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1872433-72-1

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1872433-72-1 Structure

1872433-72-1 Structure
IdentificationBack Directory
[Name]

1,1,1-Trifluoroethyl-PEG4-amine
[CAS]

1872433-72-1
[Synonyms]

1,1,1-Trifluoroethyl-PEG4-amine
3,6,9,12-Tetraoxatetradecan-1-amine, 14,14,14-trifluoro-
[Molecular Formula]

C10H20F3NO4
[MDL Number]

MFCD29079382
[MOL File]

1872433-72-1.mol
[Molecular Weight]

275.27
Chemical PropertiesBack Directory
[Boiling point ]

315.1±37.0 °C(Predicted)
[density ]

1.151±0.06 g/cm3(Predicted)
[pka]

8.74±0.10(Predicted)
Hazard InformationBack Directory
[Description]

1, 1, 1-Trifluoroethyl-PEG4-Amine is a PEG linker with a trifluoroethyl and amine moiety. The amine can react with carboxylic acids, activated NHS esters and other carbonyl compounds. The hydrophilic PEG chain increases the water solubility of the compound in aqueous media.
[Uses]

111-Trifluoroethyl-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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