1817735-43-5

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1817735-43-5 Structure

Identification	Back Directory
[Name] Amino-PEG3-sulfonic acid
[CAS] 1817735-43-5
[Synonyms] Amino-PEG3-sulfonic acid Amino-PEG3-C2-sulfonic acid Amino-PEG3-sulfonic acid HCl salt Ethanesulfonic acid, 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-
[Molecular Formula] C8H19NO6S
[MDL Number] MFCD31692199
[MOL File] 1817735-43-5.mol
[Molecular Weight] 257.3

Chemical Properties	Back Directory
[density ] 1.274±0.06 g/cm3(Predicted)
[solubility ] Soluble in Water, DMSO, DMF
[pka] 1.34±0.50(Predicted)

Hazard Information	Back Directory
[Description] Amino-PEG3-sulfonic acid HCl salt are PEG linkers containing an amine group and a sulfonic acid moiety. The amine group can react with carboxylic acids, activated NHS esters and other carbonyl groups. The sulfonic acid can undergo esterification, halogenation and displacement reactions. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media.
[Uses] Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50] PEGs
[References] [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

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