1818294-49-3

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1818294-49-3 Structure

Identification	Back Directory
[Name] Azido-PEG8-TFP ester
[CAS] 1818294-49-3
[Synonyms] N3-PEG8-TFP N3-PEG8-TFP ester Azido-PEG8-TFP ester
[Molecular Formula] C25H37F4N3O10
[MDL Number] MFCD26793787
[MOL File] 1818294-49-3.mol
[Molecular Weight] 615.58

Hazard Information	Back Directory
[Uses] Azido-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG8-TFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
[IC 50] PEGs
[References] [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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