| Chemical Properties | Back Directory | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 0.25mg/mL,DMSO: 0.15mg/mL | [form ]
A crystalline solid | [pka]
12.09±0.40(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
AZ9482 is a poly(ADP-ribose) polymerase (PARP) inhibitor (IC50s = 1, 1, 46, 640, 9, and 160 nM for PARP1, -2, -3, -6, TNKS1/PARP5a, and TNKS2, respectively). It induces centrosome declustering (EC50 = <18 nM) and a multipolar spindle phenotype in HeLa cells. AZ9482 inhibits the growth of OCI-LY19 diffuse large B cell lymphoma (DLBCL) cells (GI50 = 3 nM). | [Uses]
AZ9482 is a triple PARP1/2/6 inhibitor, with IC50 values of 1 nM, 1 nM and 640 nM for PARP1, PARP2 and PARP6, respectively[1]. | [in vivo]
AZ0108 also displays toxicity in vivo, the molecular basis of which is currently undefined, limiting pharmacological evaluation of AZ0108[1].
| [References]
[1] Ryan T Howard, et al. Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. DOI:10.1021/acschembio.9b00963 |
|
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|