| Identification | Back Directory | [Name]
4,4'-Oxybis[benzamide] | [CAS]
6336-34-1 | [Synonyms]
NSC39047
OUL35 >=98% (HPLC)
4,4'-Oxybis[benzamide]
Benzamide, 4,4'-oxybis-
ARTD10,PARP,inhibit,DNA,OUL 35,NSC 39047,apoptosis,NSC-39047,PARP10,poly ADP ribose polymerase,damage,HeLa,OUL35,Inhibitor,OUL-35 | [Molecular Formula]
C14H12N2O3 | [MDL Number]
MFCD00437390 | [MOL File]
6336-34-1.mol | [Molecular Weight]
256.26 |
| Chemical Properties | Back Directory | [Boiling point ]
488.8±30.0 °C(Predicted) | [density ]
1.298±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMF: 5 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml | [form ]
A crystalline solid | [pka]
15.76±0.50(Predicted) | [color ]
White to off-white | [InChI]
1S/C14H12N2O3/c15-13(17)9-1-5-11(6-2-9)19-12-7-3-10(4-8-12)14(16)18/h1-8H,(H2,15,17)(H2,16,18) | [InChIKey]
XZRCQWLPMXFGHE-UHFFFAOYSA-N | [SMILES]
O=C(N)C1=CC=C(OC2=CC=C(C(N)=O)C=C2)C=C1 |
| Hazard Information | Back Directory | [Uses]
OUL35 (NSC39047) is a potent and selective inhibitor of ARTD10 (PARP-10), with an IC50 of 329 nM[1]. | [Biological Activity]
OUL35 is a cell penetrantpotent and selective ARTD10/PARP10 inhibitor. OUL35 rescues HeLa cells from ARTD10 induced apoptotic cell death. | [IC 50]
ARTD10/PARP10: 329 nM (IC50) | [storage]
4°C, protect from light | [References]
[1] Harikanth Venkannagari, et al. Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage. Cell Chem Biol. 2016 Oct 20;23(10):1251-1260. DOI:10.1016/j.chembiol.2016.08.012 |
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